Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida M
PROVIDER: S-EPMC4143094 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Yoshida M M Ishiguro M M Ikejiri K K Mochizuki I I Nakamoto Y Y Kinugasa Y Y Takagane A A Endo T T Shinozaki H H Takii Y Y Mochizuki H H Kotake K K Kameoka S S Takahashi K K Watanabe T T Watanabe M M Boku N N Tomita N N Nakatani E E Sugihara K K
Annals of oncology : official journal of the European Society for Medical Oncology 20140618 9
<h4>Background</h4>S-1 is an oral fluoropyrimidine whose antitumor effects have been demonstrated in treating various gastrointestinal cancers, including metastatic colon cancer, when administered as monotherapy or in combination chemotherapy. We conducted a randomized phase III study investigating the efficacy of S-1 as adjuvant chemotherapy for colon cancer by evaluating its noninferiority to tegafur-uracil plus leucovorin (UFT/LV).<h4>Patients and methods</h4>Patients aged 20-80 years with cu ...[more]