Ontology highlight
ABSTRACT:
SUBMITTER: Norrie JL
PROVIDER: S-EPMC4143117 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Norrie Jacqueline L JL Lewandowski Jordan P JP Bouldin Cortney M CM Amarnath Smita S Li Qiang Q Vokes Martha S MS Ehrlich Lauren I R LIR Harfe Brian D BD Vokes Steven A SA
Developmental biology 20140714 2
Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of three partially redundant BMPs that are required for multiple stages of limb development. We generated an inducible allele of a BMP inhibitor, Gremlin, which reduces BMP signaling. We show that BMPs act in a dose and time dependent manner in which early reduction of BMPs result in digit loss, while ...[more]