Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.
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ABSTRACT:
SUBMITTER: Sunshine J
PROVIDER: S-EPMC4143259 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.
Sunshine Joel J Green Jordan J JJ Mahon Kerry P KP Yang Fan F Eltoukhy Ahmed A AA Nguyen David N DN Langer Robert R Anderson Daniel G DG
Advanced materials (Deerfield Beach, Fla.) 20090815 48
End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective. ...[more]
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