Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC4143385 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhang Conggang C Lee Schuyler S Peng Yinghua Y Bunker Eric E Giaime Emilie E Shen Jie J Zhou Zongyao Z Liu Xuedong X
Current biology : CB 20140731 16
<h4>Background</h4>The PINK1-Parkin pathway is known to play important roles in regulating mitochondria dynamics, motility, and quality control. Activation of this pathway can be triggered by a variety of cellular stress signals that cause mitochondrial damage. How this pathway senses different levels of mitochondrial damage and mediates cell fate decisions accordingly is incompletely understood.<h4>Results</h4>Here, we present evidence that PINK1-Parkin has both cytoprotective and proapoptotic ...[more]