Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia.
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ABSTRACT:
SUBMITTER: Matson BC
PROVIDER: S-EPMC4143458 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
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Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia.
Matson B C BC Corty R W RW Karpinich N O NO Murtha A P AP Valdar W W Grotegut C A CA Caron K M KM
Placenta 20140710 9
Levels of the peptide hormone adrenomedullin (AM) are elevated during normal pregnancy, but whether this differs during complications of pregnancy remains unresolved. AM can be quantified by measuring its pre-prohormone byproduct, midregional pro-adrenomedullin (MR-proADM). MR-proADM has shown prognostic value as a biomarker of heart failure, sepsis, and community-acquired pneumonia. Given the relevance of AM to pregnancy, we tested the hypothesis that MR-proADM provides a biomarker for preeclam ...[more]
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