Ontology highlight
ABSTRACT:
SUBMITTER: Balliu B
PROVIDER: S-EPMC4143620 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Balliu Brunilda B Uh Hae-Won HW Tsonaka Roula R Boehringer Stefan S Helmer Quinta Q Houwing-Duistermaat Jeanine J JJ
BMC proceedings 20140617 Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo
In this analysis, we investigate the contributions that linkage-based methods, such as identical-by-descent mapping, can make to association mapping to identify rare variants in next-generation sequencing data. First, we identify regions in which cases share more segments identical-by-descent around a putative causal variant than do controls. Second, we use a two-stage mixed-effect model approach to summarize the single-nucleotide polymorphism data within each region and include them as covariat ...[more]