False-positive rates in two-point parametric linkage analysis.
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ABSTRACT:
SUBMITTER: Szymczak S
PROVIDER: S-EPMC4143621 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
False-positive rates in two-point parametric linkage analysis.
Szymczak Silke S Simpson Claire L CL Cropp Cheryl D CD Bailey-Wilson Joan E JE
BMC proceedings 20140617 Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo
Two-point linkage analyses of whole genome sequence data are a promising approach to identify rare variants that segregate with complex diseases in large pedigrees because, in theory, the causal variants have been genotyped. We used whole genome sequence data and simulated traits provided by Genetic Analysis Workshop 18 to evaluate the proportion of false-positive findings in a binary trait using classic two-point parametric linkage analysis. False-positive genome-wide significant log of odds (L ...[more]
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