Ontology highlight
ABSTRACT:
SUBMITTER: Musolf A
PROVIDER: S-EPMC4143622 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Musolf Anthony A Nato Alejandro Q AQ Londono Douglas D Zhou Lisheng L Matise Tara C TC Gordon Derek D
BMC proceedings 20140617 Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo
Most association studies focus on disease risk, with less attention paid to disease progression or severity. These phenotypes require longitudinal data. This paper presents a new method for analyzing longitudinal data to map genes in both population-based and family-based studies. Using simulated systolic blood pressure measurements obtained from Genetic Analysis Workshop 18, we cluster the phenotype data into trajectory subgroups. We then use the Bayesian posterior probability of being in the h ...[more]