Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC4143713 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BMC proceedings 20140617 Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo
Testing rare variants directly is possible with next-generation sequencing technology. In this article, we propose a sliding-window-based optimal-weighted approach to test for the effects of both rare and common variants across the whole genome. We measured the genetic association between a disease and a combination of variants of a single-nucleotide polymorphism window using the newly developed tests TOW and VW-TOW and performed a sliding-window technique to detect disease-susceptible windows. ...[more]