Ontology highlight
ABSTRACT:
SUBMITTER: Lv C
PROVIDER: S-EPMC4143929 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nature communications 20140807
Force is increasingly recognized as an important element in controlling biological processes. Forces can deform native protein conformations leading to protein-specific effects. Protein-protein binding affinities may be decreased, or novel protein-protein interaction sites may be revealed, on mechanically stressing one or more components. Here we demonstrate that the calcium-binding affinity of the sixth domain of the actin-binding protein gelsolin (G6) can be enhanced by mechanical force. Our k ...[more]