Ontology highlight
ABSTRACT:
SUBMITTER: Morisaki T
PROVIDER: S-EPMC4144071 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Morisaki Tatsuya T Müller Waltraud G WG Golob Nicole N Mazza Davide D McNally James G JG
Nature communications 20140718
Although numerous live-cell measurements have shown that transcription factors (TFs) bind chromatin transiently, no measurements of transient binding have been reported at the endogenous response elements (REs) where transcription is normally induced. Here we show that at endogenous REs the transcriptionally productive specific binding of two TFs, p53 and the glucocorticoid receptor (GR), is transient. We also find that the transient residence times of GR at endogenous REs are roughly comparable ...[more]