Ontology highlight
ABSTRACT:
SUBMITTER: Balagopalan L
PROVIDER: S-EPMC4144449 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Balagopalan Lakshmi L Barr Valarie A VA Kortum Robert L RL Park Anna K AK Samelson Lawrence E LE
Journal of immunology (Baltimore, Md. : 1950) 20130313 8
A controversy has recently emerged regarding the location of the cellular pool of the adapter linker for activation of T cells (LAT) that participates in propagation of signals downstream of the TCR. In one model phosphorylation and direct recruitment of cell surface LAT to activation-induced microclusters is critical for T cell activation, whereas in the other model vesicular, but not surface, LAT participates in these processes. By using a chimeric version of LAT that can be tracked via an ext ...[more]