Ontology highlight
ABSTRACT:
SUBMITTER: Mao M
PROVIDER: S-EPMC4144835 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mao Mao M Varadarajan Sudhahar S Fukai Tohru T Bakhshi Farnaz R FR Chernaya Olga O Dudley Samuel C SC Minshall Richard D RD Bonini Marcelo G MG
PloS one 20140826 8
Nitrate tolerance developed after persistent nitroglycerin (GTN) exposure limits its clinical utility. Previously, we have shown that the vasodilatory action of GTN is dependent on endothelial nitric oxide synthase (eNOS/NOS3) activity. Caveolin-1 (Cav-1) is known to interact with NOS3 on the cytoplasmic side of cholesterol-enriched plasma membrane microdomains (caveolae) and to inhibit NOS3 activity. Loss of Cav-1 expression results in NOS3 hyperactivation and uncoupling, converting NOS3 into a ...[more]