Ontology highlight
ABSTRACT:
SUBMITTER: Vercoulen Y
PROVIDER: S-EPMC4144849 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Vercoulen Yvonne Y Bellutti Enders Felicitas F Meerding Jenny J Plantinga Maud M Elst Elisabeth F EF Varsani Hemlata H van Schieveen Christa C Bakker Mette H MH Klein Mark M Scholman Rianne C RC Spliet Wim W Ricotti Valeria V Koenen Hans J P M HJ de Weger Roel A RA Wedderburn Lucy R LR van Royen-Kerkhof Annet A Prakken Berent J BJ
PloS one 20140826 8
Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored Treg presence and function in peripheral blood and muscle of JDM patients. We analyzed number, phenotype and function of Tregs in blood from JDM patients by flow cytometry and in vitro suppression assays ...[more]