Dataset Information

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.

ABSTRACT:

Objectives

Because they are potentially modifiable and may coexist, we evaluated the combined occurrence of a reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease (PAD), including its association with exertional symptoms, physical inactivity, and impaired mobility, in sedentary elders with functional limitations.

Design

Cross sectional.

Setting

Lifestyle Interventions and Independence in Elder (LIFE) Study.

Participants

A total of 1307 sedentary community-dwelling persons, mean age 78.9, with functional limitations (Short Physical Performance Battery [SPPB] <10).

Measurements

A reduced FEV1 was defined by a z-score less than -1.64 (ResultsA combined reduced FEV1 and PAD was established in 6.0% (78/1307) of participants. However, among those who had a reduced FEV1, 34.2% (78/228) also had PAD, whereas 20.8% (78/375) of those who had PAD also had a reduced FEV1. The 2 combined conditions were associated with exertional dyspnea (adjusted odds ratio [adjOR] 2.59 [1.20-5.60]) and slow gait speed (adjOR 3.15 [1.72-5.75]) but not with exertional leg symptoms, high sedentary time, and moderate-to-severe mobility impairment.

Conclusions

In sedentary community-dwelling elders with functional limitations, a reduced FEV1 and PAD frequently coexisted and, in combination, were strongly associated with exertional dyspnea and slow gait speed (a frailty indicator that increases the risk of deleterious outcomes).

SUBMITTER: Vaz Fragoso CA

PROVIDER: S-EPMC4145029 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Publications

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.

Vaz Fragoso Carlos A CA Hsu Fang-Chi FC Brinkley Tina T Church Timothy T Liu Christine K CK Manini Todd T Newman Anne B AB Stafford Randall S RS McDermott Mary M MM Gill Thomas M TM

Journal of the American Medical Directors Association 20140625 9

<h4>Objectives</h4>Because they are potentially modifiable and may coexist, we evaluated the combined occurrence of a reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease (PAD), including its association with exertional symptoms, physical inactivity, and impaired mobility, in sedentary elders with functional limitations.<h4>Design</h4>Cross sectional.<h4>Setting</h4>Lifestyle Interventions and Independence in Elder (LIFE) Study.<h4>Participants</h4>A total of 1307 se ...[more]

PMID: 24973990

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Dataset Information

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.

Objectives

Design

Setting

Participants

Measurements

Conclusions

Publications

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations.

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