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Natriuretic peptides as biomarkers in heart failure.


ABSTRACT: Following the initial discovery of a natriuretic and diuretic peptide factor present in atrial myocardial tissue homogenates, subsequent elucidation of the natriuretic peptide (NP) family has led to substantial advances in the understanding of the autocrine, paracrine, and endocrine regulation of the cardiovascular system. Furthermore, with the development of assays for the measurement of the NPs, these important biomarkers have gone from being regarded as biological mediators of the cardiovascular system to now represent important clinical tools for the diagnostic and prognostic evaluation of patients with heart failure and may have potential as a therapeutic target in this setting as well. An historical perspective on the NPs from bench to bedside translation will be discussed.

SUBMITTER: Januzzi JL 

PROVIDER: S-EPMC4145592 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Natriuretic peptides as biomarkers in heart failure.

Januzzi James L JL  

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20130801 6


Following the initial discovery of a natriuretic and diuretic peptide factor present in atrial myocardial tissue homogenates, subsequent elucidation of the natriuretic peptide (NP) family has led to substantial advances in the understanding of the autocrine, paracrine, and endocrine regulation of the cardiovascular system. Furthermore, with the development of assays for the measurement of the NPs, these important biomarkers have gone from being regarded as biological mediators of the cardiovascu  ...[more]

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