Dataset Information

Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.

ABSTRACT: Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.

SUBMITTER: Ballantyne KN

PROVIDER: S-EPMC4145662 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.

Ballantyne Kaye N KN Ralf Arwin A Aboukhalid Rachid R Achakzai Niaz M NM Anjos Maria J MJ Ayub Qasim Q Balažic Jože J Ballantyne Jack J Ballard David J DJ Berger Burkhard B Bobillo Cecilia C Bouabdellah Mehdi M Burri Helen H Capal Tomas T Caratti Stefano S Cárdenas Jorge J Cartault François F Carvalho Elizeu F EF Carvalho Monica M Cheng Baowen B Coble Michael D MD Comas David D Corach Daniel D D'Amato Maria E ME Davison Sean S de Knijff Peter P De Ungria Maria Corazon A MC Decorte Ronny R Dobosz Tadeusz T Dupuy Berit M BM Elmrghni Samir S Gliwiński Mateusz M Gomes Sara C SC Grol Laurens L Haas Cordula C Hanson Erin E Henke Jürgen J Henke Lotte L Herrera-Rodríguez Fabiola F Hill Carolyn R CR Holmlund Gunilla G Honda Katsuya K Immel Uta-Dorothee UD Inokuchi Shota S Jobling Mark A MA Kaddura Mahmoud M Kim Jong S JS Kim Soon H SH Kim Wook W King Turi E TE Klausriegler Eva E Kling Daniel D Kovačević Lejla L Kovatsi Leda L Krajewski Paweł P Kravchenko Sergey S Larmuseau Maarten H D MH Lee Eun Young EY Lessig Ruediger R Livshits Ludmila A LA Marjanović Damir D Minarik Marek M Mizuno Natsuko N Moreira Helena H Morling Niels N Mukherjee Meeta M Munier Patrick P Nagaraju Javaregowda J Neuhuber Franz F Nie Shengjie S Nilasitsataporn Premlaphat P Nishi Takeki T Oh Hye H HH Olofsson Jill J Onofri Valerio V Palo Jukka U JU Pamjav Horolma H Parson Walther W Petlach Michal M Phillips Christopher C Ploski Rafal R Prasad Samayamantri P R SP Primorac Dragan D Purnomo Gludhug A GA Purps Josephine J Rangel-Villalobos Hector H Rębała Krzysztof K Rerkamnuaychoke Budsaba B Gonzalez Danel Rey DR Robino Carlo C Roewer Lutz L Rosa Alexandra A Sajantila Antti A Sala Andrea A Salvador Jazelyn M JM Sanz Paula P Schmitt Cornelia C Sharma Anil K AK Silva Dayse A DA Shin Kyoung-Jin KJ Sijen Titia T Sirker Miriam M Siváková Daniela D Skaro Vedrana V Solano-Matamoros Carlos C Souto Luis L Stenzl Vlastimil V Sudoyo Herawati H Syndercombe-Court Denise D Tagliabracci Adriano A Taylor Duncan D Tillmar Andreas A Tsybovsky Iosif S IS Tyler-Smith Chris C van der Gaag Kristiaan J KJ Vanek Daniel D Völgyi Antónia A Ward Denise D Willemse Patricia P Yap Eric P H EP Yong Rita Y Y RY Pajnič Irena Zupanič IZ Kayser Manfred M

Human mutation 20140714 8

Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of ...[more]

PMID: 24917567

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Project description:Men are more susceptible to impulsive behavior than women. Epidemiological studies revealed that the impulsive aggressive behavior is affected by genetic factors, and the male-specific Y chromosome plays an important role in this behavior. In this study, we investigated the association between the impulsive aggressive behavior and Y-chromosomal short tandem repeats (Y-STRs) loci.The collected biologic samples from 271 offenders with impulsive aggressive behavior and 492 healthy individuals without impulsive aggressive behavior were amplified by PowerPlexRY23 PCR System and the resultant products were separated by electrophoresis and further genotyped. Then, comparisons in allele and haplotype frequencies of the selected 22 Y-STRs were made in the two groups.Our results showed that there were significant differences in allele frequencies at DYS448 and DYS456 between offenders and controls (p < .05). Univariate analysis further revealed significant frequency differences for alleles 18 and 22 at DYS448 (0.18 vs 0.27, compared to the controls, p = .003, OR=0.57,95% CI=0.39-0.82; 0.03 vs 0.01, compared to the controls, p = .003, OR=7.45, 95% CI=1.57-35.35, respectively) and for allele 17 at DYS456 (0.07 vs 0.14, compared to the controls, p = .006, OR=0.48, 95% CI =0.28-0.82) between two groups. Interestingly, the frequency of haploid haplotype 22-15 on the DYS448-DYS456 (DYS448-DYS456-22-15) was significantly higher in offenders than in controls (0.033 vs 0.004, compared to the control, p = .001, OR = 8.42, 95%CI =1.81-39.24). Moreover, there were no significant differences in allele frequencies of other Y-STRs loci between two groups. Furthermore, the unconditional logistic regression analysis confirmed that alleles 18 and 22 at DYS448 and allele 17 at DYS456 are associated with male impulsive aggression. However, the DYS448-DYS456-22-15 is less related to impulsive aggression.Our results suggest a link between Y-chromosomal allele types and male impulsive aggression.

Dataset Information

Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.

Publications

Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.

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