Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.
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ABSTRACT:
SUBMITTER: Hashmi B
PROVIDER: S-EPMC4146397 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.
Hashmi Basma B Zarzar Lauren D LD Mammoto Tadanori T Mammoto Akiko A Jiang Amanda A Aizenberg Joanna J Ingber Donald E DE
Advanced materials (Deerfield Beach, Fla.) 20140218 20
A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo. ...[more]
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