Ontology highlight
ABSTRACT:
SUBMITTER: Papanikolaou X
PROVIDER: S-EPMC4147310 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Papanikolaou Xenofon X Johnson Sarah S Garg Tarun T Tian Erming E Tytarenko Ruslana R Zhang Qing Q Stein Caleb C Barlogie Bart B Epstein Joshua J Heuck Christoph C
Oncotarget 20140601 12
Although novel drugs have contributed immensely to improving outcomes of patients with multiple myeloma (MM), many patients develop drug resistance and ultimately succumb to MM. Here, we show that artesunate, an anti-malarial drug, reliably induces cell death in vitro in naïve as well as drug-resistant MM cells at concentrations shown to be safe in humans. Artesunate induced apoptosis predominantly through the non-caspase mediated pathway by primarily targeting mitochondria and causing outer mit ...[more]