Ontology highlight
ABSTRACT:
SUBMITTER: Thakur S
PROVIDER: S-EPMC4147320 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Thakur Satbir S Singla Arvind K AK Chen Jie J Tran Uyen U Yang Yang Y Salazar Carolina C Magliocco Anthony A Klimowicz Alexander A Jirik Frank F Riabowol Karl K
Oncotarget 20140601 12
INhibitor of Growth 1 (ING1) expression is repressed in breast carcinomas, but its role in breast cancer development and metastasis is unknown. ING1 levels were quantified in >500 patient samples using automated quantitative fluorescence immunohistochemistry, and data were analysed for correlations to patient outcome. Effects of altering ING levels were examined in microarrays and metastasis assays in vitro, and in a mouse metastasis model in vivo. ING1 levels were lower in tumors compared to ad ...[more]