Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines.
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ABSTRACT:
SUBMITTER: Cluzeau T
PROVIDER: S-EPMC4147331 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Phenotypic and genotypic characterization of azacitidine-sensitive and resistant SKM1 myeloid cell lines.
Cluzeau Thomas T Dubois Alix A Jacquel Arnaud A Luciano Frederic F Renneville Aline A Preudhomme Claude C Karsenti Jean Michel JM Mounier Nicolas N Rohrlich Pierre P Raynaud Sophie S Mari Bernard B Robert Guillaume G Auberger Patrick P
Oncotarget 20140601 12
In the present study, we provide a comparative phenotypic and genotypic analysis of azacitidine-sensitive and resistant SKM-1 cell lines. Morphologically, SKM1-R exhibited increase in cell size that accounts for by enhanced ploidy in a majority of cells as shown by cell cycle and karyotype analysis. No specific Single Nucleotide Polymorphism (SNP) alteration was found in SKM1-R cells compared to their SKM1-S counterpart. Comparative pangenomic profiling revealed the up-regulation of a panel of g ...[more]
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