Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC4147379 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Huang Chao C Chen Mina M Pang Dejiang D Bi Dandan D Zou Yi Y Xia Xiaoqiang X Yang Weiwei W Luo Liping L Deng Rongkang R Tan Honglin H Zhou Liang L Yu Shouyang S Guo Liheng L Du XiaoXia X Cui Yiyuan Y Hu Jiahua J Mao Qing Q Worley Paul F PF Xiao Bo B
Developmental cell 20140801 4
Production of reactive oxygen species (ROS) increases with neuronal activity that accompanies synaptic development and function. Transcription-related factors and metabolic enzymes that are expressed in all tissues have been described to counteract neuronal ROS to prevent oxidative damage. Here, we describe the antioxidant gene LanCL1 that is prominently enriched in brain neurons. Its expression is developmentally regulated and induced by neuronal activity, neurotrophic factors implicated in neu ...[more]