HubAlign: an accurate and efficient method for global alignment of protein-protein interaction networks.

ABSTRACT:

Motivation

High-throughput experimental techniques have produced a large amount of protein-protein interaction (PPI) data. The study of PPI networks, such as comparative analysis, shall benefit the understanding of life process and diseases at the molecular level. One way of comparative analysis is to align PPI networks to identify conserved or species-specific subnetwork motifs. A few methods have been developed for global PPI network alignment, but it still remains challenging in terms of both accuracy and efficiency.

Results

This paper presents a novel global network alignment algorithm, denoted as HubAlign, that makes use of both network topology and sequence homology information, based upon the observation that topologically important proteins in a PPI network usually a

SUBMITTER: Hashemifar S 

PROVIDER: S-EPMC4147903 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature