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Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

ABSTRACT: Two novel synthetic ?2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and ?2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.

SUBMITTER: Yu H 

PROVIDER: S-EPMC4147952 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

Yu Hai H   Lau Kam K   Thon Vireak V   Autran Chloe A CA   Jantscher-Krenn Evelyn E   Xue Mengyang M   Li Yanhong Y   Sugiarto Go G   Qu Jingyao J   Mu Shengmao S   Ding Li L   Bode Lars L   Chen Xi X  

Angewandte Chemie (International ed. in English) 20140521 26

Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necroti  ...[more]