Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya R
PROVIDER: S-EPMC4148232 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bhattacharya Raja R Touroutine Denis D Barbagallo Belinda B Climer Jason J Lambert Christopher M CM Clark Christopher M CM Alkema Mark J MJ Francis Michael M MM
PLoS genetics 20140828 8
An organism's ability to thrive in changing environmental conditions requires the capacity for making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis elegans, foraging responses to changes in food availability require nlp-12, a homolog of the mammalian neuropeptide cholecystokinin (CCK). nlp-12 expression is limited to a single interneuron (DVA) that is postsynaptic to dopaminergic neurons involved in food-sensing, and presynaptic to locomotory control neurons. N ...[more]