Ontology highlight
ABSTRACT:
SUBMITTER: Blisnick T
PROVIDER: S-EPMC4148251 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Blisnick Thierry T Buisson Johanna J Absalon Sabrina S Marie Alexandra A Cayet Nadège N Bastin Philippe P
Molecular biology of the cell 20140702 17
Cilia and flagella are assembled by intraflagellar transport (IFT) of protein complexes that bring tubulin and other precursors to the incorporation site at their distal tip. Anterograde transport is driven by kinesin, whereas retrograde transport is ensured by a specific dynein. In the protist Trypanosoma brucei, two distinct genes encode fairly different dynein heavy chains (DHCs; ∼40% identity) termed DHC2.1 and DHC2.2, which form a heterodimer and are both essential for retrograde IFT. The s ...[more]