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Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

ABSTRACT: A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated ("putative progressors", PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (TSCM (p<0.0001), which was associated with decreased HIV infection of these cells in VNPs (r?=?-0.649, p?=?0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (TCM) cells (p?=?0.035), and the total number of TCM cells was associated with increased proliferation of memory CD4+ T cells (r?=?0.733, p?=?0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ TCM and TSCM, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia.

SUBMITTER: Klatt NR

PROVIDER: S-EPMC4148445 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

Klatt Nichole R NR Bosinger Steven E SE Peck Melicent M Richert-Spuhler Laura E LE Heigele Anke A Gile Jillian P JP Patel Nirav N Taaffe Jessica J Julg Boris B Camerini David D Torti Carlo C Martin Jeffrey N JN Deeks Steven G SG Sinclair Elizabeth E Hecht Frederick M FM Lederman Michael M MM Paiardini Mirko M Kirchhoff Frank F Brenchley Jason M JM Hunt Peter W PW Silvestri Guido G

PLoS pathogens 20140828 8

A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated ("putative progressors", PP), thus avoiding the confounding effec ...[more]

PMID: 25167059

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Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

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Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

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