Ontology highlight
ABSTRACT:
SUBMITTER: Costa-Mattioli M
PROVIDER: S-EPMC4149214 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Costa-Mattioli Mauro M Gobert Delphine D Stern Elad E Gamache Karine K Colina Rodney R Cuello Claudio C Sossin Wayne W Kaufman Randal R Pelletier Jerry J Rosenblum Kobi K Krnjević Kresimir K Lacaille Jean-Claude JC Nader Karim K Sonenberg Nahum N
Cell 20070401 1
The late phase of long-term potentiation (LTP) and memory (LTM) requires new gene expression, but the molecular mechanisms that underlie these processes are not fully understood. Phosphorylation of eIF2alpha inhibits general translation but selectively stimulates translation of ATF4, a repressor of CREB-mediated late-LTP (L-LTP) and LTM. We used a pharmacogenetic bidirectional approach to examine the role of eIF2alpha phosphorylation in synaptic plasticity and behavioral learning. We show that i ...[more]