Ontology highlight
ABSTRACT:
SUBMITTER: Smith JF
PROVIDER: S-EPMC4149303 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Smith James F JF Yango Pamela P Altman Eran E Choudhry Shweta S Poelzl Andrea A Zamah Alberuni M AM Rosen Mitchell M Klatsky Peter C PC Tran Nam D ND
Stem cells translational medicine 20140718 9
Prepubertal boys treated with high-dose chemotherapy do not have an established means of fertility preservation because no established in vitro technique exists to expand and mature purified spermatogonial stem cells (SSCs) to functional sperm in humans. In this study, we define and characterize the unique testicular cellular niche required for SSC expansion using testicular tissues from men with normal spermatogenesis. Highly purified SSCs and testicular somatic cells were isolated by fluoresce ...[more]