Ontology highlight
ABSTRACT:
SUBMITTER: Ishida S
PROVIDER: S-EPMC4149355 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ishida Sumire S Tanaka Ryosuke R Yamaguchi Naoya N Ogata Genki G Mizutani Takeomi T Kawabata Kazushige K Haga Hisashi H
PloS one 20140829 8
Lumen formation is important for morphogenesis; however, an unanswered question is whether it involves the collective migration of epithelial cells. Here, using a collagen gel overlay culture method, we show that Madin-Darby canine kidney cells migrated collectively and formed a luminal structure in a collagen gel. Immediately after the collagen gel overlay, an epithelial sheet folded from the periphery, migrated inwardly, and formed a luminal structure. The inhibition of integrin-β1 or Rac1 act ...[more]