Ontology highlight
ABSTRACT:
SUBMITTER: He MC
PROVIDER: S-EPMC4149419 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
He Mi-chun MC Wang Jun J Wu Jian J Gong Fang-yuan FY Hong Chao C Xia Yun Y Zhang Li-juan LJ Bao Wan-rong WR Gao Xiao-Ming XM
PloS one 20140829 8
We have recently demonstrated that the greatly increased immunological activities of recombinant murine calreticulin (rCRT) are largely attributed to its self-oligomerization. Although native CRT (nCRT) can also oligomerize under stress conditions in vitro, whether this phenomenon could occur inside cells and the immunological activity difference between nCRT monomers and oligomers remained unclear. In this study, we illustrated the formation of CRT oligomers in tranfectant cells under "heat & l ...[more]