Ontology highlight
ABSTRACT:
SUBMITTER: Aceto N
PROVIDER: S-EPMC4149753 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Aceto Nicola N Bardia Aditya A Miyamoto David T DT Donaldson Maria C MC Wittner Ben S BS Spencer Joel A JA Yu Min M Pely Adam A Engstrom Amanda A Zhu Huili H Brannigan Brian W BW Kapur Ravi R Stott Shannon L SL Shioda Toshi T Ramaswamy Sridhar S Ting David T DT Lin Charles P CP Toner Mehmet M Haber Daniel A DA Maheswaran Shyamala S
Cell 20140801 5
Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with tagged mammary tumors, we demonstrate that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascular aggregation events. Although rare in the circulation compared with single CTCs, CTC clusters have 23- to 50-fold increased metastatic potential. In patients with breast cancer, single-cell resolu ...[more]