Ontology highlight
ABSTRACT:
SUBMITTER: Rapin N
PROVIDER: S-EPMC4150216 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Oncogenesis 20140616
Reciprocal chromosomal translocations are observed in one-third of acute myeloid leukemia (AML) cases. Targeting and understanding the effects of the resulting aberrant oncogenic fusion proteins may help developing drugs against specific leukemic subtypes, as demonstrated earlier by the use of ATRA in acute promyelocytic leukemia. Hematopoietic stem/progenitor (HSPCs) cells transduced with oncogenic fusion genes are regarded as promising in vitromodels of their corresponding AML subtypes. Here, ...[more]