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Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.

ABSTRACT: We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant.The results disclosed statistical difference between allele distribution among cases and controls (p=0.025, odds ratio=1.58, confidence interval=1.07-2.32) considering VDR FokI/T2C polymorphism.The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested.

SUBMITTER: Vieira LA 

PROVIDER: S-EPMC4150369 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.

Vieira Luiz Angelo LA   De Marchi Patricia Leme PL   dos Santos Aline Amaro AA   Christofolini Denise Maria DM   Barbosa Caio Parente CP   Fonseca Fernando Luiz Affonso FL   Bianco Bianca B   Rodrigues Luciano Miller R LM  

Genetic testing and molecular biomarkers 20140709 9

<h4>Aim</h4>We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.<h4>Methods</h4>A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square  ...[more]

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