Dataset Information
Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.
Ontology highlight
ABSTRACT: Aim
We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.Methods
A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant.Results
The results disclosed statistical difference between allele distribution among cases and controls (p=0.025, odds ratio=1.58, confidence interval=1.07-2.32) considering VDR FokI/T2C polymorphism.Conclusion
The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested.
SUBMITTER: Vieira LA
PROVIDER: S-EPMC4150369 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration.
Genetic testing and molecular biomarkers 20140709 9
<h4>Aim</h4>We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism.<h4>Methods</h4>A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square ...[more]
