Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC4150825 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Zhang Peijing P Wei Yongkun Y Wang Li L Debeb Bisrat G BG Yuan Yuan Y Zhang Jinsong J Yuan Jingsong J Wang Min M Chen Dahu D Sun Yutong Y Woodward Wendy A WA Liu Yongqing Y Dean Douglas C DC Liang Han H Hu Ye Y Ang K Kian KK Hung Mien-Chie MC Chen Junjie J Ma Li L
Nature cell biology 20140803 9
Epithelial-mesenchymal transition (EMT) is associated with characteristics of breast cancer stem cells, including chemoresistance and radioresistance. However, it is unclear whether EMT itself or specific EMT regulators play causal roles in these properties. Here we identify an EMT-inducing transcription factor, zinc finger E-box binding homeobox 1 (ZEB1), as a regulator of radiosensitivity and DNA damage response. Radioresistant subpopulations of breast cancer cells derived from ionizing radiat ...[more]