Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka M
PROVIDER: S-EPMC4151072 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Monoclonal antibodies in immunodiagnosis and immunotherapy 20140801 4
Fibroblast growth factor-2 (FGF-2) plays a critical role in endothelial survival, proliferation, and angiogenesis and is localized on the cell membrane by binding to heparan sulfate proteoglycans. Here we established a neutralizing monoclonal antibody, 1B9B9, against FGF-2 using the rat medial iliac lymph node method. 1B9B9 blocked the binding of FGF-2 to its receptor, inhibiting FGF-2-induced proliferation and corresponding downstream signaling in endothelial cells. Treatment of human umbilical ...[more]