Dataset Information

Reduced prevalence of cognitive impairment in families with exceptional longevity.

ABSTRACT: IMPORTANCE:Family studies of centenarians and long-lived persons have found substantial familial aggregation of survival to extreme ages; however, the extent to which such familial longevity is characterized by cognitively intact survival is not established. OBJECTIVE:To determine whether families with exceptional longevity are protected against cognitive impairment consistent with Alzheimer disease. DESIGN:Cross-sectional analysis. SETTING:Multisite study in New York, Massachusetts, Pennsylvania, and Denmark. PARTICIPANTS:A total of 1870 individuals (1510 family members and 360 spouse controls) recruited through the Long Life Family Study. MAIN OUTCOME AND MEASURE:Prevalence of cognitive impairment based on a diagnostic algorithm validated using the National Alzheimer's Coordinating Center data set. RESULTS:The cognitive algorithm classified 546 individuals (38.5%) as having cognitive impairment consistent with Alzheimer disease. Long Life Family Study probands had a slightly but not statistically significant reduced risk of cognitive impairment compared with spouse controls (121 of 232 for probands vs 45 of 103 for spouse controls; odds ratio?=?0.7; 95% CI, 0.4-1.4), whereas Long Life Family Study sons and daughters had a clearly reduced risk of cognitive impairment (11 of 213 for sons and daughters vs 28 of 216 for spouse controls; odds ratio?=?0.4; 95% CI, 0.2-0.9). Restriction to nieces and nephews in the offspring generation attenuated this effect (37 of 328 for nieces and nephews vs 28 of 216 for spouse controls; odds ratio?=?0.8; 95% CI, 0.4-1.4). CONCLUSIONS AND RELEVANCE:Rates of cognitive impairment characteristic of Alzheimer disease were relatively high. In the proband generation, rates were comparable across family members and spouse controls, whereas sons and daughters of probands had significantly lower rates than spouse controls. Results suggest a delayed onset of cognitive impairment in families with exceptional longevity, but assessment of age-specific incidence rates is required to confirm this hypothesis.

SUBMITTER: Cosentino S

PROVIDER: S-EPMC4151346 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Reduced prevalence of cognitive impairment in families with exceptional longevity.

Cosentino Stephanie S Schupf Nicole N Christensen Kaare K Andersen Stacy L SL Newman Anne A Mayeux Richard R

JAMA neurology 20130701 7

<h4>Importance</h4>Family studies of centenarians and long-lived persons have found substantial familial aggregation of survival to extreme ages; however, the extent to which such familial longevity is characterized by cognitively intact survival is not established.<h4>Objective</h4>To determine whether families with exceptional longevity are protected against cognitive impairment consistent with Alzheimer disease.<h4>Design</h4>Cross-sectional analysis.<h4>Setting</h4>Multisite study in New Yor ...[more]

PMID: 23649824

Similar Datasets

Project description:BackgroundCognitive impairment seems to be frequent in intracerebral hemorrhage (ICH) survivors, but remains widely understudied. In this study, we investigated the frequency and patterns of vascular cognitive disorders (VCDs) in patients with cerebral amyloid angiopathy (CAA)-related and deep ICH compared to patients with mild cognitive impairment due to Alzheimer's disease (MCI-AD) and healthy controls.MethodsWe prospectively recruited 20 patients with CAA-related lobar ICH, 20 with deep ICH, 20 with MCI-AD and 17 healthy controls. Patients with cognitive decline pre-ICH were excluded from the analysis. Each participant underwent a comprehensive neuropsychological assessment and a structural brain MRI. Cognitive assessment was performed at a median delay of 4 months after the acute phase in ICH patients, and more than 6 months after the first complaint in MCI-AD patients. Cognitive profiles were compared between groups. The prevalence of VCDs in the ICH groups was estimated using the recent VASCOG criteria.Results"Mild" and "major VCDs" were respectively observed in 87.5% and 2.5% of all ICH patients. Every patient in the CAA group had mild VCDs. No significant difference was observed in cognitive functioning between CAA-related and deep ICH patients. The most impaired process in the CAA group was naming, with a mean (±standard deviation) z-score of -5.2 ±5.5, followed by processing speed (-4.1±3.3), executive functioning (-2.6 ±2.5), memory (-2.4 ±3.5) and attention (-0.9 ±1.3). This cognitive pattern was different from the MCI-AD patients, but the groups were only different in gestural praxis, and by construction, in memory processes.ConclusionsVCDs are frequent after ICH. Cognitive patterns of patients with deep or CAA-related ICH did not differ, but there was impaired performance in specific domains distinct from the effects of Alzheimer's disease.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01619709.

Dataset Information

Reduced prevalence of cognitive impairment in families with exceptional longevity.

Publications

Reduced prevalence of cognitive impairment in families with exceptional longevity.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets