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A prospective assessment of reports of drinking to self-medicate mood symptoms with the incidence and persistence of alcohol dependence.

ABSTRACT: Mood disorders and alcohol dependence frequently co-occur. Etiologic theories concerning the comorbidity often focus on drinking to self-medicate or cope with affective symptoms. However, there have been few, if any, prospective studies in population-based samples of alcohol self-medication of mood symptoms with the occurrence of alcohol dependence. Furthermore, it is not known whether these associations are affected by treatment or symptom severity.To evaluate the hypothesis that alcohol self-medication of mood symptoms increases the probability of subsequent onset and the persistence or chronicity of alcohol dependence.Prospective study using face-to-face interviews-the National Epidemiologic Survey on Alcohol and Related Conditions.Nationally representative survey of the US population.Drinkers at risk for alcohol dependence among the 43?093 adults surveyed in 2001 and 2002 (wave 1); 34?653 of whom were reinterviewed in 2004 and 2005 (wave 2).Association of alcohol self-medication of mood symptoms with incident and persistent DSM-IV alcohol dependence using logistic regression and the propensity score method of inverse probability of treatment weighting.The report of alcohol self-medication of mood symptoms was associated with an increased odds of incident alcohol dependence at follow-up (adjusted odds ratio [AOR], 3.10; 95% CI, 1.55-6.19; P?=?.002) and persistence of dependence (AOR, 3.45; 95% CI, 2.35-5.08; P?

SUBMITTER: Crum RM

PROVIDER: S-EPMC4151472 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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A prospective assessment of reports of drinking to self-medicate mood symptoms with the incidence and persistence of alcohol dependence.

Crum Rosa M RM Mojtabai Ramin R Lazareck Samuel S Bolton James M JM Robinson Jennifer J Sareen Jitender J Green Kerry M KM Stuart Elizabeth A EA La Flair Lareina L Alvanzo Anika A H AA Storr Carla L CL

JAMA psychiatry 20130701 7

<h4>Importance</h4>Mood disorders and alcohol dependence frequently co-occur. Etiologic theories concerning the comorbidity often focus on drinking to self-medicate or cope with affective symptoms. However, there have been few, if any, prospective studies in population-based samples of alcohol self-medication of mood symptoms with the occurrence of alcohol dependence. Furthermore, it is not known whether these associations are affected by treatment or symptom severity.<h4>Objective</h4>To evalua ...[more]

PMID: 23636710

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Project description:BackgroundSelf-reported consumption is pervasive in alcohol research, though retrospective recall bias is a concern. Fine-grained methods are designed to limit retrospection; yet, discrepancies can arise when comparing responses on fine-grained surveys with responses to retrospective surveys across weeks or months. Many fine-grained studies use both repeated daily surveys (RDS) and end-of-day (EOD) summaries, but little research has examined whether these survey types are consistent. The purpose of this study was to quantify the magnitude and directionality of discrepancy between EOD summaries and RDS and identify alcohol-related predictors of discrepancy.MethodsAs a part of a larger study, college student alcohol and cannabis users (N = 341; 53% women; Mage = 19.79 years) were recruited to complete 56 days of data collection, including 5 daily assessments of their substance use and related constructs, one of which included an EOD summary of the previous day. Generalized linear mixed-effects models were used to examine between- and within-person predictors of a 5-category, discrepancy outcome: no discrepancy, low discrepancy where RDS < EOD, low discrepancy where EOD < RDS, high discrepancy where RDS < EOD, and high discrepancy where EOD < RDS.ResultsDiscrepancies between EOD and RDS were observed in both directions. Alcohol problems predicted more alcohol consumption reported on the EOD survey than across RDS. Within-person alcohol quantity and hourly rate of consumption were most strongly related to less alcohol consumption reported on the EOD survey. Between- and within-person peak subjective intoxication and within-person liquor consumption were associated with discrepancies in both directions.ConclusionsSurveys requiring more retrospection may overestimate alcohol consumption in problematic drinkers and underestimate consumption on days where more alcohol is consumed than typical. Evidence also suggests that greater day-to-day instability in alcohol behavior is linked to less consistent reporting overall. More research is needed to discern factors contributing to inconsistent reporting on fine-grained surveys to maximize the validity of reports.

Dataset Information

A prospective assessment of reports of drinking to self-medicate mood symptoms with the incidence and persistence of alcohol dependence.

Publications

A prospective assessment of reports of drinking to self-medicate mood symptoms with the incidence and persistence of alcohol dependence.

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