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Modular o-quinone catalyst system for dehydrogenation of tetrahydroquinolines under ambient conditions.

ABSTRACT: Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we report the design and development of new o-quinone-based catalysts for the oxidative dehydrogenation of tetrahydroquinolines to afford quinolines. Use of a Co(salophen) cocatalyst allows the reaction to proceed efficiently with ambient air at room temperature. The utility of the catalytic method is demonstrated in the preparation of a number of medicinally relevant quinolines.

SUBMITTER: Wendlandt AE

PROVIDER: S-EPMC4151779 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Modular o-quinone catalyst system for dehydrogenation of tetrahydroquinolines under ambient conditions.

Wendlandt Alison E AE Stahl Shannon S SS

Journal of the American Chemical Society 20140819 34

Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we report the design and development of new o-quinone-based catalysts for the oxidative dehydrogenation of tetrahydroquinolines to afford quinolines. Use of a Co(salophen) cocatalyst allows the reaction to proceed efficiently with ambient air at room temperature. The utility of the catalytic method is demonstrated in the preparation of a number of medicinally relevant quinol ...[more]

PMID: 25109345

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