Ontology highlight
ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC4151877 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lee Jonas Y JY Yang Janet G JG Zhitnitsky Daniel D Lewinson Oded O Rees Douglas C DC
Science (New York, N.Y.) 20140301 6175
Although substantial progress has been achieved in the structural analysis of exporters from the superfamily of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, much less is known about how they selectively recognize substrates and how substrate binding is coupled to ATP hydrolysis. We have addressed these questions through crystallographic analysis of the Atm1/ABCB7/HMT1/ABCB6 ortholog from Novosphingobium aromaticivorans DSM 12444, NaAtm1, at 2.4 angstrom resolution. Consisten ...[more]