Ontology highlight
ABSTRACT:
SUBMITTER: Capolicchio S
PROVIDER: S-EPMC4153399 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Capolicchio Samanta S Wang Huanchen H Thakor Divyeshsinh T DT Shears Stephen B SB Jessen Henning J HJ
Angewandte Chemie (International ed. in English) 20140714 36
The ubiquitous mammalian signaling molecule bis-diphosphoinositol tetrakisphosphate (1,5-(PP)2 -myo-InsP4 , or InsP8 ) displays the most congested three-dimensional array of phosphate groups found in nature. The high charge density, the accumulation of unstable P-anhydrides and P-esters, the lack of UV absorbance, and low levels of optical rotation constitute severe obstacles to its synthesis, characterization, and purification. Herein, we describe the first procedure for the synthesis of enanti ...[more]