Ontology highlight
ABSTRACT:
SUBMITTER: Saeed AM
PROVIDER: S-EPMC4153630 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Saeed Ali M AM Duffort Stephanie S Ivanov Dmitry D Wang Hua H Laird James M JM Salomon Robert G RG Cruz-Guilloty Fernando F Perez Victor L VL
PloS one 20140903 9
Oxidative stress is key in the pathogenesis of several diseases including age-related macular degeneration (AMD), atherosclerosis, diabetes, and Alzheimer's disease. It has previously been established that a lipid peroxidation product, carboxyethylpyrrole (CEP), accumulates in the retinas of AMD patients. Retinal infiltrating macrophages also accumulate in the retinas of both AMD patients and in a murine model of AMD. We therefore investigated the ability of CEP-adducts to activate innate immune ...[more]