High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.
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ABSTRACT:
SUBMITTER: Davies S
PROVIDER: S-EPMC4153698 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.
Davies Suzy S Holmes Anna A Lomo Lesley L Steinkamp Mara P MP Kang Huining H Muller Carolyn Y CY Wilson Bridget S BS
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 20140701 4
Ovarian cancer is the leading cause of death from gynecologic cancers in the United States. Failure may be due to variable expression and/or complex interactions of growth factor receptors in individual tumors. As ErbB3-MET cooperativity is implicated in solid tumor resistance to EGFR/ErbB2 inhibitors, we evaluated expression of MET and all 4 ErbB family members in ovarian cancers. Tissue arrays were prepared from archival formalin-fixed paraffin-embedded tumor samples, including 202 ovarian car ...[more]
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