Ontology highlight
ABSTRACT:
SUBMITTER: Park DY
PROVIDER: S-EPMC4153702 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Park Dae-Young DY Lee Junyeop J Park Intae I Choi Dongwon D Lee Sunju S Song Sukhyun S Hwang Yoonha Y Hong Ki Yong KY Nakaoka Yoshikazu Y Makinen Taija T Kim Pilhan P Alitalo Kari K Hong Young-Kwon YK Koh Gou Young GY
The Journal of clinical investigation 20140725 9
Schlemm's canal (SC) is a specialized vascular structure in the eye that functions to drain aqueous humor from the intraocular chamber into systemic circulation. Dysfunction of SC has been proposed to underlie increased aqueous humor outflow (AHO) resistance, which leads to elevated ocular pressure, a factor for glaucoma development in humans. Here, using lymphatic and blood vasculature reporter mice, we determined that SC, which originates from blood vessels during the postnatal period, acquire ...[more]