Ontology highlight
ABSTRACT:
SUBMITTER: Bertet C
PROVIDER: S-EPMC4153738 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bertet Claire C Li Xin X Erclik Ted T Cavey Matthieu M Wells Brent B Desplan Claude C
Cell 20140801 5
Temporal patterning of neural progenitors is one of the core mechanisms generating neuronal diversity in the central nervous system. Here, we show that, in the tips of the outer proliferation center (tOPC) of the developing Drosophila optic lobes, a unique temporal series of transcription factors not only governs the sequential production of distinct neuronal subtypes but also controls the mode of progenitor division, as well as the selective apoptosis of Notch(OFF) or Notch(ON) neurons during b ...[more]