Ontology highlight
ABSTRACT:
SUBMITTER: El Fatimy R
PROVIDER: S-EPMC4154132 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
El Fatimy Rachid R Miozzo Federico F Le Mouël Anne A Abane Ryma R Schwendimann Leslie L Sabéran-Djoneidi Délara D de Thonel Aurélie A Massaoudi Illiasse I Paslaru Liliana L Hashimoto-Torii Kazue K Christians Elisabeth E Rakic Pasko P Gressens Pierre P Mezger Valérie V
EMBO molecular medicine 20140801 8
Fetal alcohol spectrum disorder (FASD) is a frequent cause of mental retardation. However, the molecular mechanisms underlying brain development defects induced by maternal alcohol consumption during pregnancy are unclear. We used normal and Hsf2-deficient mice and cell systems to uncover a pivotal role for heat shock factor 2 (HSF2) in radial neuronal migration defects in the cortex, a hallmark of fetal alcohol exposure. Upon fetal alcohol exposure, HSF2 is essential for the triggering of HSF1 ...[more]