Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC4154226 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Wang Li L Du Ying Y Ward James M JM Shimbo Takashi T Lackford Brad B Zheng Xiaofeng X Miao Yi-liang YL Zhou Bingying B Han Leng L Fargo David C DC Jothi Raja R Williams Carmen J CJ Wade Paul A PA Hu Guang G
Cell stem cell 20140501 5
The master transcription factors play integral roles in the pluripotency transcription circuitry of embryonic stem cells (ESCs). How they selectively activate expression of the pluripotency network while simultaneously repressing genes involved in differentiation is not fully understood. Here, we define a requirement for the INO80 complex, a SWI/SNF family chromatin remodeler, in ESC self-renewal, somatic cell reprogramming, and blastocyst development. We show that Ino80, the chromatin remodelin ...[more]