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A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.

ABSTRACT: Metal chelators masked with protecting groups for targeted release have the potential to conditionally modulate cellular metals. We report a new route to prepare cis-cinnamate protecting groups that enabled development of a prochelator with chemical stimulus response, fluorescent reporting and active compound release in a single structure.

SUBMITTER: Franks AT

PROVIDER: S-EPMC4154376 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.

Franks Andrew T AT Franz Katherine J KJ

Chemical communications (Cambridge, England) 20141001 77

Metal chelators masked with protecting groups for targeted release have the potential to conditionally modulate cellular metals. We report a new route to prepare cis-cinnamate protecting groups that enabled development of a prochelator with chemical stimulus response, fluorescent reporting and active compound release in a single structure. ...[more]

PMID: 25116739

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