Three-residue loop closure in proteins: a new kinematic method reveals a locus of connected loop conformations.
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ABSTRACT:
SUBMITTER: Nekouzadeh A
PROVIDER: S-EPMC4154380 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Three-residue loop closure in proteins: a new kinematic method reveals a locus of connected loop conformations.
Journal of computational chemistry 20110526 12
The closure of a three-residue loop was studied using a developed kinematic method. It was shown that there are infinite number of three-residue loops (a locus of conformations), which can connect two segments of a polypeptide. This adds to the current understanding of a finite number of conformations for three-residue loop-closure. In the developed method, some of the equations can be solved analytically to reduce the computation cost. Benefiting from the reduced computation time, we determined ...[more]
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