Sequence-based antigenic change prediction by a sparse learning method incorporating co-evolutionary information.

ABSTRACT: Rapid identification of influenza antigenic variants will be critical in selecting optimal vaccine candidates and thus a key to developing an effective vaccination program. Recent studies suggest that multiple simultaneous mutations at antigenic sites accumulatively enhance antigenic drift of influenza A viruses. However, pre-existing methods on antigenic variant identification are based on analyses from individual sites. Because the impacts of these co-evolved sites on influenza antigenicity may not be additive, it will be critical to quantify the impact of not only those single mutations but also multiple simultaneous mutations or co-evolved sites. Here, we developed and applied a computational method, AntigenCO, to identify and quantify both single and co-evolutionary sites driving the

SUBMITTER: Yang J 

PROVIDER: S-EPMC4154722 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature